Biologists & Medicine · Medicine
Doudna, Charpentier & CRISPR
From a bacterial immune system to programmable gene editing: Mojica's repeats, the 2012 Science paper, Cas9 and guide RNA, the patent fight with the Broad Institute, the first CRISPR therapy (Casgevy, 2023), and the He Jiankui scandal.
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Key idea
Prereqs: Watson-Crick-Franklin; viruses & bacteria. Next: AI for science. Sources: Jinek et al., *Science* (2012); Walter Isaacson, *The Code Breaker* (2021); Nobel Prize in Chemistry 2020; FDA approval of Casgevy (Dec 2023).Next: 1. Timeline