Biology · Biology
Biotech & CRISPR
How a bacterial immune system became a gene editor: Cas9 and guide RNA, Doudna and Charpentier's 2012 paper, base and prime editing, the first approved CRISPR therapy for sickle cell disease, agriculture, and the ethics after the 2018 gene-edited babies.
Step 1 of 6 · Overview30 min read ·
Key idea
Prereqs: Genetics & inheritance; Viruses & bacteria. Next: Biotech as an industry. Sources: Jinek, Chylinski, Fonfara, Hauer, Doudna & Charpentier (Science, 2012); Walter Isaacson, *The Code Breaker* (2021); FDA approval of Casgevy (December 2023).Next: 1. From bacteria to tool